21045
Fluka
Calcium Ionophore A23187
BioChemika, free acid, ~95% (HPLC)
| Synonym: | Antibiotic A 23187, Calimycin |
| CAS Number: | 52665-69-7 |
| Linear Formula: | C29H37N3O6 |
| Molecular Weight: | 523.62 |
| Beilstein Registry Number: | 1096801 |
| EC Number: | 258-084-1 |
| MDL number: | MFCD00151202 |
Description
| Application | Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase. |
| Other Notes | A23187 increases the permeability of biological membranes with a high selectivity for Ca2+. It is used extensively in studies related to intracellular Ca2+,1,2,3 |
Properties
| product line | BioChemika |
| assay | ~95% (HPLC) |
| mp | 187-190 °C |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | DM4676000 |
References
| Cited Reference | 1. B.C. Pressmann Annu. Rev. Biochem. 45, 501, (1976) Abstract |
| 2. W.Y. Cheung, ed. Calcium and Cell Function New York vol. 1-7, (1980) | |
| 3. A.K. Campbell Intracellular Calcium New York , (1983) | |
| reference | Pressman, B.C., et al., Biological applications of ionophores. Annu. Rev. Biochem. 45, 50-530, (1976) |
| Kauffman, R.F., et al., Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. J. Biol. Chem. 255, 2735-2739, (1980) | |
| Markram, H., and Segal, M., Calcimycin potentiates responses of rat hippocampal neurons to N-methyl-D-aspartate. Brain Res. 540, 322-324, (1991) | |
| Knowles, R.G., and Moncada, S., Nitric oxide as a signal in blood vessels. Trends Biochem. Sci. 17, 399-402, (1992) | |
| Merck | Merck 13,1639 |
